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Cryopreservation of Human Gametes

What is Cryopreservation?

Cryopreservation is a widely used fertility technique where human gametes (sperm, eggs) or embryos are preserved by freezing them at extremely low temperatures using liquid nitrogen. This process ensures long-term storage without affecting their functionality. Modern methods such as vitrification prevent ice crystal formation by rapidly cooling embryos into a glass-like state, making the procedure highly effective in assisted reproduction.

When to Consider Cryopreservation?

Embryos and gametes are highly sensitive to temperature fluctuations. Sudden freezing can damage tissues, so cryoprotectants are used to protect the cells during freezing, improving their survival rate—a process known as cryo-survival.

Applications of Cryopreservation in Fertility

  • Preserves eggs and sperm for couples facing fertility challenges.
  • Helps patients with low sperm quality avoid donor sperm usage.
  • Provides backup embryos in case of unsuccessful IVF attempts.
  • Supports fertility preservation for future pregnancies.

At fertility centers like Progenesis, cryopreserved gametes are carefully handled to ensure fertility potential remains intact, even in patients with normal semen profiles.

Conditions of Cryopreservation

  • Embryos are thawed after storage and transferred once tests confirm readiness.
  • Multiple eggs are stimulated to allow backup embryos for future use.
  • If one embryo leads to pregnancy, remaining embryos can be preserved for later cycles.
  • Semen can be stored for up to a year without loss of quality under cryopreservation.

Benefits of Cryopreservation

  • Extends fertility options for men and women.
  • Supports patients undergoing medical treatments (e.g., cancer therapy).
  • Improves IVF success rates by offering multiple transfer opportunities.
  • Reduces need for repeated egg retrieval cycles.

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