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Intra-Cytoplasmic Morphologically-Selected Sperm Injection (IMSI)

Male Infertility Treatments

Intra-Cytoplasmic Morphologically-Selected Sperm Injection (IMSI)

Intra-Cytoplasmic Morphologically-Selected Sperm Injection (IMSI)

IMSI is an advanced IVF technique designed to improve fertilization outcomes by selecting the best-quality sperm under very high magnification. This method is especially useful in cases of male infertility related to poor sperm morphology, DNA fragmentation, or repeated IVF/ICSI failures.

When to Consider IMSI?

  • Teratozoospermia (abnormally shaped sperm affecting embryo development)
  • High DNA fragmentation in sperm reducing fertilization quality
  • Repeated ICSI failures without successful pregnancy
  • Sperm retrieval cases such as azoospermia
  • Recurrent miscarriages, particularly first-trimester losses

How is IMSI Performed?

  • Ovarian Stimulation: The female partner undergoes stimulation to develop multiple healthy follicles.
  • Egg Retrieval: Mature oocytes are collected for fertilization.
  • Sperm Examination: Sperm are analyzed under 6600x magnification to detect structural abnormalities.
  • Sperm Selection: A single healthy, morphologically normal sperm is selected.
  • Fertilization: The chosen sperm is injected directly into the egg (similar to ICSI).
  • Embryo Transfer: The resulting embryo is cultured and transferred to the uterus.

Benefits of IMSI

  • Improves embryo quality by using only the healthiest sperm
  • Enhances chances of successful implantation and pregnancy
  • Reduces risk of miscarriage, especially in recurrent cases
  • Provides higher success rates in couples with previous IVF/ICSI failures
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